Global analyses within the Standard Model Effective Field Theory (SMEFT) framework provide a powerful approach to exploring potential directions for new physics. As experimental data continue to grow in both volume and precision, incorporating higher-order contributions becomes increasingly important from a theoretical perspective. These contributions manifest in two critical ways: next-to-leading order (NLO) corrections to observables and the effects of renormalization group evolution (RGE), the latter being essential for a consistent treatment of the large scale separation inherent in combined SMEFT analyses. In this work, we investigate the impact of including NLO corrections and RGE effects in a global SMEFT fit, assuming a 𝑈(3)5 flavour symmetry for dimension-six operators. Our analysis yields two significant findings: it places tighter constraints on previously weakly constrained coefficients and uncovers new correlations among coefficients that are uncorrelated at tree level. These results underscore the substantial influence of NLO and RGE effects on the bounds of SMEFT Wilson coefficients.