The decay of B mesons can be predicted within the Heavy Quark Expansion as the decay of a free bottom quark plus corrections which are
suppressed by powers of $1/m_b$. This contribution describes the calculation
of the NNLO QCD corrections to nonleptonic decays of a free bottom quark
including charm quark mass effects. In particular it outlines the
challenges in connection to the computation of master integrals, the
renormalization of the effective operators and the problems
which arise from calculating traces with $\gamma_5$ in $d$ dimensions.