A novel approach is proposed to link the charge symmetry breaking (CSB) nuclear interaction and the low-energy constants in quantum chromodynamics (QCD) for the first time by matching the CSB effect in nuclear matter. Resulting CSB interaction is applied to study the Okamoto- Nolen-Schiffer anomaly, still lacking of a satisfactory microscopic understanding, on the energy differences of mirror nuclei by taking 17F-17O, 15O-15N, 41Sc-41Ca, and 39Ca-39K as typical examples. The QCD-based CSB interactions are found to resolve the anomaly successfully within theoretical uncertainties.