The origin and propagation of cosmic rays remain open questions in the field of cosmic rays. One way to explore these questions is to study the flux ratios of different elements, including secondary-to-primary ratios. The Cosmic Ray Energetics And Mass instrument on the International Space Station (ISS-CREAM) was built to measure the cosmic-ray elements from protons to iron nuclei with energies up to the cosmic-ray knee. We present the flux ratios of various elements with data collected during ISS-CREAM on-orbit operations, including the boron-to-carbon ratio.