The Galactic Center (GC) region has long been subject to intense interest within the astrophysics community. At the GC, a strong radio source has been detected and identified as the super-massive black hole, Sgr. A*, which significantly affects the dynamics of the GC region within 300 parsecs. Many interesting astrophysical objects, including supernova remnants, high-mass X-ray binaries, pulsar wind nebulae, among others, have been found in this region. These objects are expected to produce high energy neutrinos, possibly in a transient manner, which can potentially be observed with the IceCube Neutrino Observatory. Due to the geographical location of the IceCube Neutrino Observatory, a large amount of cosmic-ray muons reduces IceCube's sensitivity in the southern sky, where the GC is located. Thus, a dedicated event selection is performed to reduce this background and optimize the sensitivity. In this talk, we present this event selection in the GC region with IceCube data using classical and machine learning methods. This new dataset will be used to perform a time-dependent search for single flares at the GC.