We present results on the axial, scalar and tensor isovector-couplings of the nucleon from 2+1 flavor lattice QCD with physical light quarks ($m_\pi = 135~{\rm MeV}$) in large spatial volume of ($10.8~\rm fm)^3$. The calculations are carried out with the PACS10 gauge configurations generated by the PACS Collaboration with the stout-smeared $\mathcal{O}(a)$ improved Wilson fermions and Iwasaki gauge action at $\beta=1.82$ corresponding to the lattice spacing of $\rm 0.084~fm$.
For the renormalization, we use the RI/SMOM scheme, a variant of Rome-Southampton RI/MOM scheme with reduced systematic errors, as the intermediate scheme. We then evaluate our final results in the $\overline{\rm MS}$ scheme at a scale of $\rm 2~GeV$, using the continuum perturbation theory for the matching scale of RI/SMOM and $\overline{\rm MS}$ schemes and running.