Since December 2015 the DAMPE (DArk Matter Particle Experiment) detector is on-orbit at an altitude of 500 km and takes data smoothly. It consists of a Plastic Scintillator strip Detector (PSD), a Silicon-Tungsten tracKer-converter (STK), a BGO imaging calorimeter and a NeUtron Detector (NUD). The charge of incident cosmic rays (CRs) is measured by looking at the energy deposited in the PSD, and the tracks are reconstructed thanks to the high spatial resolution of the STK. The remarkable depth (32 radiation lengths) of the calorimeter allows for an estimate of the CR energy. Then the DAMPE features are suitable to distinguish the elemental composition of CRs and to measure their fluxes in the energy range of 20 GeV - 100 TeV. Here the analysis progress in the study of the Helium component will be presented and discussed.