We study the five chirality-flipping interactions that appear in the top-Higgs sector at leading order in the standard model effective field theory. We consider constraints from collider observables, flavor physics, and electric-dipole-moment experiments. This analysis results in very competitive constraints from indirect observables when one considers a single coupling at a time. In addition, we discuss how these limits are affected in scenarios in which multiple top-Higgs interactions are generated at the scale of new physics.