We present in the following a new type of front-end electronics which has been developed for
the detection of the optical Cherenkov signals by Extensive Air Showers directly observed from
sub-orbital and orbital altitudes. It adopts a new generation of low-power consuming 64-channel Application-Specific Integrated Circuit (ASIC). The ASIC is implemented in a commercial 65 nm CMOS technology to readout an 8×8 matrix of SiPMs. The event is recorded in an array of 256 cells, each one equipped with an analog memory, a 12-bits Wilkinson Analog-to-Digital Converter (ADC) and latches running at a sampling rate of 200 MS/s. The converted data are sent off-chip to an FPGA which controls the readout operations of the ASIC channels and implements the trigger logic. The goal is to employ it on experiments either on balloon platforms or space-based which are devoted to Ultra-High Energy Cosmic Ray and neutrino astronomy from space through the detection of atmospheric Cherenkov light. We discuss in the following its suitability for EUSO-SPB2-like missions on board stratospheric balloons and for the Terzina project, part of the NUSES space mission.