The PIONEERS-selected mission TIGERISS, planned to launch to the ISS in 2026, will provide, for the first time, single-element resolution Galactic cosmic-ray elemental abundances spanning the periodic table, from 5B up to 82Pb, to further our understanding of the grand cycle of matter in the Galaxy. Such wide-range, fine-resolution experimental data would be best combined with the latest developments in astrophysical models, but the current accuracy of nuclear isotopic production cross sections is far behind the accuracy delivered by space instrumentation. We are updating the current cross section library employed by the GALPROP framework for propagation of Galactic cosmic rays and diffuse emissions with newer reaction channels and more accurate data on existing channels that have been reported over the last two decades. This will provide a crucial update to the state-of-the-art tool widely used by the community to explore the information encoded in the chemical composition of cosmic rays. Our main focus are the proton spallation reactions on 1) isotopes of 5B through 82Pb, and 2) the sub-Fe group; we are also concentrating on the electron-capture isotopes which provide additional constrains on the processes involving energy gain and loss by cosmic rays species in the interstellar medium and the heliosphere.