This work discusses four different algorithms for the minimization of threshold dispersion in
multichannel readout circuits for pixel detectors. These algorithms, which are based on different
methods (e.g. charge scans, threshold scans, etc) and differs in terms of performance and computation time, have been tested on the asynchronous front-end integrated in the CHIPIX65_FE0, a readout ASIC prototype designed in a 65 nm CMOS technology.